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Porcine Small Intestinal Submucosa (SIS)

Porcine small intestinal submucosa (e.g., Surgisis, Stratasis) is a decellularized ECM derived from porcine small bowel. It was applied in urogynecologic prolapse and sling surgery in the 1990s–2000s.

Composition​

  • Acellular extracellular matrix of porcine jejunal submucosa
  • Collagen-rich with preserved glycosaminoglycans and growth factors
  • Designed to serve as a resorbable remodeling scaffold

Evidence & Current Status​

  • No consistent advantage over native-tissue repair for prolapse
  • Inconsistent tissue incorporation; unpredictable remodeling
  • Most products have been withdrawn from urogynecologic use
  • Persisting applications in general surgery (hernia repair) where context differs

See also: Porcine Acellular Collagen Matrix, Decellularized ECM.