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Coaptite — Calcium Hydroxyapatite

Coaptite is a calcium hydroxyapatite (CaHA) microsphere suspension in an aqueous gel carrier — a bulking agent for female SUI.

Composition​

  • CaHA microspheres (75–125 μm) in aqueous gel carrier
  • CaHA is biocompatible (same mineral as bone)
  • Microspheres induce local fibrosis; gel carrier absorbs after injection

Evidence​

  • Long-term efficacy 60–75%[1][2]
  • Notably higher rate of temporary urinary retention (34.2%) compared with other agents — a significant early morbidity

Contemporary Use​

Less commonly used than Bulkamid or Macroplastique in the current SUI landscape. The retention profile and availability of better-tolerated alternatives have narrowed its indications.

References​

1. Hoe V, Haller B, Yao HH, O'Connell HE. Urethral Bulking Agents for the Treatment of Stress Urinary Incontinence in Women: A Systematic Review. Neurourology and Urodynamics. 2021;40(6):1349–1388. doi:10.1002/nau.24696

2. Hussain SM, Bray R. Urethral Bulking Agents for Female Stress Urinary Incontinence. Neurourology and Urodynamics. 2019;38(3):887–892. doi:10.1002/nau.23924

See also: Bulkamid.